Second, we present, in detail and for the first time, what these prominent regulatory questions are for all relevant risk assessment endpoints.
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These detailed regulatory questions were derived in part from the EU FP 7 research programme NANoREG, and then augmented by additional questions that have been raised by regulatory authorities. These questions address the following areas: 1 physicochemical characterization, 2 exposure through the lifecycle, 3 fate — persistence — bioaccumulation, 4 modeling of environmental fate and exposure, 5 ecological effects and biokinetics, 6 human health effects and biokinetics in vivo , 7 human health effects and biokinetics in vitro , 8 in silico strategies — Q SAR modeling, and 9 risk assessment.
Answers to these questions were provided by an expert solicitation in the EU H coordination activity ProSafe, were presented and discussed at a scientific conference at OECD in November , and are now published separately in this special issue of NanoImpact. The methods deemed acceptable for regulatory use, and targeted regulatory gaps, will be incorporated into a draft white paper.
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Fish cell lines as a tool for the ecotoxicity assessment and ranking of engineered nanomaterials. Regulatory Toxicology and Pharmacology , 90 , William K. Boyes, Brittany Lila M.
Thornton, Souhail R. Al-Abed, Christian P. Andersen, Dermont C. Bouchard, Robert M. Burgess, Elaine A. Cohen Hubal, Kay T.
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Modelling the Toxicity of Nanoparticles
Chen, Aleksandr Stefaniak, Kevin C. Jordan, Roy R. Whitney, Dale W. Porter, Aaron D. Acute in vitro and in vivo toxicity of a commercial grade boron nitride nanotube mixture. Small , 13 33 , Andrew Barrick, Am? The role of high-throughput screening in ecotoxicology and engineered nanomaterials.
(PDF) Nanomedicine: Overview, Problem, Solution and Future | Dr. Seun Ebiesuwa - furremahtai.tk
Environmental Toxicology and Chemistry , 36 7 , Hsiang-Chun Hsueh, Deborah S. Jacobs, Justin M. Gorham, Savelas A. Rabb, Lee L. Journal of Coatings Technology and Research , 14 4 , Safety assessment of nanomaterials using an advanced decision-making framework, the DF4nanoGrouping. Tinh Nguyen, Elijah J. Petersen, Bastien Pellegrin, Justin M. Impact of UV irradiation on multiwall carbon nanotubes in nanocomposites: Formation of entangled surface layer and mechanisms of release resistance.
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